Nobiletin Delays Aging and Enhances Stress Resistance of Caenorhabditis elegans
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چکیده
منابع مشابه
The GATA Transcription Factor egl-27 Delays Aging by Promoting Stress Resistance in Caenorhabditis elegans
Stress is a fundamental aspect of aging, as accumulated damage from a lifetime of stress can limit lifespan and protective responses to stress can extend lifespan. In this study, we identify a conserved Caenorhabditis elegans GATA transcription factor, egl-27, that is involved in several stress responses and aging. We found that overexpression of egl-27 extends the lifespan of wild-type animals...
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Much attention has been focused on the hypothesis that oxidative damage plays in cellular and organismal aging. A mev-1 (kn1) mutant of Caenorhabditis elegans, isolated on the basis of its methyl viologen (paraquat) hypersensitivity, is also hypersensitive to elevated oxygen levels. Unlike the wild type, its life span decreases dramatically as oxygen concentrations are increased from 1% to 60%....
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The antioxidant properties of l-arginine (l-Arg) in vivo, and its effect on enhancing resistance to oxidative stress and heat stress in Caenorhabditis elegans were investigated. C. elegans, a worm model popularly used in molecular and developmental biology, was used in the present study. Here, we report that l-Arg, at a concentration of 1 mM, prolonged C. elegans life by 26.98% and 37.02% under...
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The senescent decline that leads inevitably to death in most animal species is accompanied by a massive increase in molecular damage. Yet, the chain of events that initially causes this process, and the determinants of the rate at which it happens, remain poorly understood. For many years, much research on this topic has been guided by an interrelated set of theories that view oxidative damage ...
متن کاملMechanisms of aging: neuronal orchestration of stress resistance and protein homeostasis in the nematode Caenorhabditis elegans
5 CHAPTER 1: RELATED LITERATURE 7 1.1. Aging 9 1.1.1. Aging as a regulated process 9 1.1.1.1. In search for a valuable approach to study stress resistance, proteostasis, and aging: Caenorhabditis elegans as a resourceful model 10 1.1.1.2. The insulin/IGF-1 signaling (IIS) pathway 12 1.1.1.3. Does the regulation of aging oppose cumulative damages? 15 1.2. The proteome and its challenges 15 1.2.1...
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ژورنال
عنوان ژورنال: International Journal of Molecular Sciences
سال: 2020
ISSN: 1422-0067
DOI: 10.3390/ijms21010341